| 持股明細(資料日期：2025/08/31) |
| 持股名稱 | 比例 |
| GILEAD SCIENCES INC | 7.36% |
| AMGEN INC | 7.11% |
| REGENERON PHARMACEUTICALS | 6.38% |
| VERTEX PHARMACEUTICALS INC | 6.26% |
| ALNYLAM PHARMACEUTICALS INC | 5.40% |
| ASTRAZENECA PLC-SPONS ADR | 4.92% |
| INSMED INC | 2.62% |
| ARGENX SE - ADR | 2.44% |
| BIOGEN INC | 2.17% |
| SUMMIT THERAPEUTICS INC | 2.01% |
| INCYTE CORP | 1.83% |
| ILLUMINA INC | 1.75% |
| PROSHARES ULTRA NASD BIOTECH | 1.70% |
| ROYALTY PHARMA PLC- CL A | 1.68% |
| SANOFI-ADR | 1.57% |
| UNITED THERAPEUTICS CORP | 1.54% |
| NEUROCRINE BIOSCIENCES INC | 1.51% |
| Medpace Holdings Inc | 1.47% |
| VIATRIS INC | 1.39% |
| TEMPUS AI INC | 1.36% |
| ASCENDIS PHARMA A/S - ADR | 1.30% |
| BIOMARIN PHARMACEUTICAL INC | 1.29% |
| EXELIXIS INC | 1.19% |
| BIONTECH SE-ADR | 1.18% |
| MODERNA INC | 1.09% |
| MADRIGAL PHARMACEUTICALS INC | 1.05% |
| BRIDGEBIO PHARMA INC | 1.02% |
| HALOZYME THERAPEUTICS INC | 1.00% |
| Roivant Sciences Ltd | 0.95% |
| Jazz Pharmaceuticals Plc | 0.93% |
| GUARDANT HEALTH INC | 0.87% |
| VERONA PHARMA PLC - ADR | 0.87% |
| REVOLUTION MEDICINES INC | 0.76% |
| IONIS PHARMACEUTICALS INC | 0.74% |
| AXSOME THERAPEUTICS INC | 0.63% |
| RHYTHM PHARMACEUTICALS INC | 0.63% |
| AVIDITY BIOSCIENCES INC | 0.58% |
| NUVALENT INC-A | 0.57% |
| MIRUM PHARMACEUTICALS INC | 0.57% |
| KRYSTAL BIOTECH INC | 0.54% |
| CYTOKINETICS INC | 0.53% |
| VAXCYTE INC | 0.52% |
| MERUS NV | 0.46% |
| ALKERMES PLC | 0.46% |
| ACADIA PHARMACEUTICALS INC | 0.43% |
| CRISPR Therapeutics AG | 0.43% |
| ADMA BIOLOGICS INC | 0.41% |
| SCHOLAR ROCK HOLDING CORP | 0.39% |
| PROTAGONIST THERAPEUTICS INC | 0.37% |
| AKERO THERAPEUTICS INC | 0.37% |
| PTC THERAPEUTICS INC | 0.36% |
| APELLIS PHARMACEUTICALS INC | 0.35% |
| ARCELLX INC | 0.35% |
| Sarepta Therapeutics Inc | 0.30% |
| XENON PHARMACEUTICALS INC | 0.29% |
| AMNEAL PHARMACEUTICALS INC | 0.28% |
| CRINETICS PHARMACEUTICALS IN | 0.27% |
| ULTRAGENYX PHARMACEUTICAL IN | 0.26% |
| NEWAMSTERDAM PHARMA CO NV | 0.26% |
| IMMUNOVANT INC | 0.25% |
| ALVOTECH SA | 0.24% |
| LIGAND PHARMACEUTICALS | 0.23% |
| AMICUS THERAPEUTICS INC | 0.23% |
| Indivior PLC | 0.22% |
| ARROWHEAD PHARMACEUTICALS IN | 0.22% |
| KYMERA THERAPEUTICS INC | 0.21% |
| CG ONCOLOGY INC | 0.20% |
| RECURSION PHARMACEUTICALS-A | 0.19% |
| VERACYTE INC | 0.19% |
| AGIOS PHARMACEUTICALS INC | 0.19% |
| DENALI THERAPEUTICS INC | 0.17% |
| BEAM THERAPEUTICS INC | 0.17% |
| Harmony Biosciences Holdings | 0.17% |
| SUPERNUS PHARMACEUTICALS INC | 0.16% |
| IDEAYA BIOSCIENCES INC | 0.15% |
| TARSUS PHARMACEUTICALS INC | 0.15% |
| DISC MEDICINE INC | 0.14% |
| IMMUNITYBIO INC | 0.14% |
| OCULAR THERAPEUTIX INC | 0.13% |
| KINIKSA PHARMACEUTICALS INTE | 0.13% |
| VERICEL CORP | 0.12% |
| APOGEE THERAPEUTICS INC | 0.12% |
| SYNDAX PHARMACEUTICALS INC | 0.12% |
| Twist Bioscience Corp | 0.12% |
| Adaptive Biotechnologies | 0.11% |
| AMPHASTAR PHARMACEUTICALS IN | 0.11% |
| AURINIA PHARMACEUTICALS INC | 0.11% |
| BIOCRYST PHARMACEUTICALS INC | 0.11% |
| WAVE LIFE SCIENCES LTD | 0.11% |
| ANI Pharmaceuticals Inc | 0.11% |
| MANNKIND CORP | 0.11% |
| HARROW INC | 0.11% |
| AVADEL PHARMACEUTICALS | 0.11% |
| ARS PHARMACEUTICALS INC | 0.11% |
| DYNE THERAPEUTICS INC | 0.11% |
| IMMUNOCORE HOLDINGS PLC-ADR | 0.10% |
| 89BIO INC | 0.10% |
| EDGEWISE THERAPEUTICS INC | 0.10% |
| JANUX THERAPEUTICS INC | 0.10% |
| Novocure Ltd | 0.10% |
| ARCUTIS BIOTHERAPEUTICS INC | 0.10% |
| 10X GENOMICS INC-CLASS A | 0.10% |
| Intellia Therapeutics Inc | 0.09% |
| NOVAVAX INC | 0.09% |
| VERA THERAPEUTICS INC | 0.09% |
| ARDELYX INC | 0.09% |
| COGENT BIOSCIENCES INC | 0.08% |
| CENTESSA PHARMACEUTICALS-ADR | 0.08% |
| STRUCTURE THERAPEUTICS INC | 0.08% |
| GRAIL INC | 0.08% |
| GRIFOLS SA-ADR | 0.08% |
| DYNAVAX TECHNOLOGIES CORP | 0.08% |
| Innoviva Inc | 0.08% |
| PACIRA BIOSCIENCES INC | 0.08% |
| CUREVAC NV | 0.08% |
| ABCELLERA BIOLOGICS INC | 0.08% |
| COLLEGIUM PHARMACEUTICAL INC | 0.08% |
| TRAVERE THERAPEUTICS INC | 0.07% |
| Precigen Inc | 0.07% |
| SANA BIOTECHNOLOGY INC | 0.07% |
| GERON CORP | 0.07% |
| SPYRE THERAPEUTICS INC | 0.07% |
| ZYMEWORKS INC | 0.07% |
| FORTREA HOLDINGS INC | 0.07% |
| STOKE THERAPEUTICS INC | 0.07% |
| LENZ THERAPEUTICS INC | 0.07% |
| CORMEDIX INC | 0.06% |
| XERIS BIOPHARMA HOLDINGS INC | 0.06% |
| PHATHOM PHARMACEUTICALS INC | 0.06% |
| PRAXIS PRECISION MEDICINES I | 0.06% |
| GENMAB A/S -SP ADR | 0.06% |
| DAY ONE BIOPHARMACEUTICALS I | 0.06% |
| IOVANCE BIOTHERAPEUTICS INC | 0.06% |
| KURA ONCOLOGY INC | 0.05% |
| KEROS THERAPEUTICS INC | 0.05% |
| NURIX THERAPEUTICS INC | 0.05% |
| ARVINAS INC | 0.05% |
| VIR BIOTECHNOLOGY INC | 0.05% |
| ENLIVEN THERAPEUTICS INC | 0.05% |
| PHIBRO ANIMAL HEALTH CORP-A | 0.05% |
| TANGO THERAPEUTICS INC | 0.05% |
| MIND MEDICINE MINDMED INC | 0.05% |
| RAPPORT THERAPEUTICS INC | 0.04% |
| ORUKA THERAPEUTICS INC | 0.04% |
| ANAVEX LIFE SCIENCES CORP | 0.04% |
| AMYLYX PHARMACEUTICALS INC | 0.04% |
| MINERALYS THERAPEUTICS INC | 0.04% |
| TAYSHA GENE THERAPIES INC | 0.04% |
| CULLINAN THERAPEUTICS INC | 0.04% |
| ARRIVENT BIOPHARMA INC | 0.04% |
| TYRA BIOSCIENCES INC | 0.04% |
| uniQure NV | 0.04% |
| RIGEL PHARMACEUTICALS INC | 0.04% |
| Theravance Biopharma Inc | 0.04% |
| EYEPOINT PHARMACEUTICALS INC | 0.04% |
| GALAPAGOS NV-SPON ADR | 0.04% |
| SIGA TECHNOLOGIES INC | 0.03% |
| KALVISTA PHARMACEUTICALS INC | 0.03% |
| ARCTURUS THERAPEUTICS HOLDIN | 0.03% |
| PROTHENA CORP PLC | 0.03% |
| Arbutus Biopharma Corp | 0.03% |
| Xencor Inc | 0.03% |
| AnaptysBio Inc | 0.03% |
| UROGEN PHARMA LTD | 0.03% |
| RELAY THERAPEUTICS INC | 0.03% |
| TOURMALINE BIO INC | 0.03% |
| ORIC PHARMACEUTICALS INC | 0.03% |
| SAVARA INC | 0.03% |
| CASTLE BIOSCIENCES INC | 0.03% |
| MESOBLAST LTD- SPON ADR | 0.03% |
| ZEVRA THERAPEUTICS INC | 0.03% |
| TECTONIC THERAPEUTIC INC | 0.03% |
| ALUMIS INC | 0.03% |
| TREVI THERAPEUTICS INC | 0.03% |
| NEUMORA THERAPEUTICS INC | 0.02% |
| AURA BIOSCIENCES INC | 0.02% |
| INHIBRX BIOSCIENCES INC | 0.02% |
| ASTRIA THERAPEUTICS INC | 0.02% |
| NEUROGENE INC | 0.02% |
| 4D MOLECULAR THERAPEUTICS IN | 0.02% |
| FOGHORN THERAPEUTICS INC | 0.02% |
| MONTE ROSA THERAPEUTICS INC | 0.02% |
| TERNS PHARMACEUTICALS INC | 0.02% |
| ABSCI CORP | 0.02% |
| MARAVAI LIFESCIENCES HLDGS-A | 0.02% |
| OLEMA PHARMACEUTICALS INC | 0.02% |
| CARTESIAN THERAPEUTICS INC | 0.02% |
| BICYCLE THERAPEUTICS PLC-ADR | 0.02% |
| DESIGN THERAPEUTICS INC | 0.02% |
| Y-MABS THERAPEUTICS INC | 0.02% |
| CORVUS PHARMACEUTICALS INC | 0.02% |
| AMARIN CORP PLC -ADR | 0.02% |
| EVOLUS INC | 0.02% |
| REPLIMUNE GROUP INC | 0.02% |
| REGENXBIO INC | 0.02% |
| Esperion Therapeutics Inc | 0.02% |
| ALTIMMUNE INC | 0.02% |
| VANDA PHARMACEUTICALS INC | 0.02% |
| OMEROS CORP | 0.02% |
| PACIFIC BIOSCIENCES OF CALIF | 0.02% |
| ROCKET PHARMACEUTICALS INC | 0.02% |
| AQUESTIVE THERAPEUTICS INC | 0.02% |
| MeiraGTx Holdings plc | 0.02% |
| PERSONALIS INC | 0.02% |
| ATEA PHARMACEUTICALS INC | 0.02% |
| PRIME MEDICINE INC | 0.02% |
| OMNIAB INC | 0.01% |
| LEXICON PHARMACEUTICALS INC | 0.01% |
| COMPASS Pathways Plc | 0.01% |
| VOYAGER THERAPEUTICS INC | 0.01% |
| Allogene Therapeutics Inc | 0.01% |
| EDITAS MEDICINE INC | 0.01% |
| NKARTA INC | 0.01% |
| ANNEXON INC | 0.01% |
| CODEXIS INC | 0.01% |
| PLIANT THERAPEUTICS INC | 0.01% |
| MACROGENICS INC | 0.01% |
| IRONWOOD PHARMACEUTICALS INC | 0.01% |
| AC IMMUNE SA | 0.01% |
| AUTOLUS THERAPEUTICS PLC | 0.01% |
| SOLID BIOSCIENCES INC | 0.01% |
| FATE THERAPEUTICS INC | 0.01% |
| LYELL IMMUNOPHARMA INC | 0.01% |
| C4 THERAPEUTICS INC | 0.01% |
| ERASCA INC | 0.01% |
| HUMACYTE INC | 0.01% |
| MAXCYTE INC | 0.01% |
| ALECTOR INC | 0.01% |
| TEVOGEN BIO HOLDINGS INC | 0.01% |
| LARIMAR THERAPEUTICS INC | 0.01% |
| ALPHA TEKNOVA INC | 0.01% |
| ENTRADA THERAPEUTICS INC | 0.01% |
| LEXEO THERAPEUTICS INC | 0.01% |
| SCPHARMACEUTICALS INC | 0.01% |
| KYVERNA THERAPEUTICS INC | 0.01% |
| CLIMB BIO INC | 0.01% |
| SILENCE THERAPEUTICS PLC-ADR | 0.01% |